After a run of dangerous luck, John (Steve Buscemi), a compulsive gambler, runs away from Las Vegas and towards a traditional job and life. Taking a nondescript position in an auto insurance firm in Albuquerque, he tries to get ahead in the straight world, amid the ever-current temptations of scratch-off lotto tickets.
When his boss, Mr. Townsend (Peter Dinklage), asks John to accompany his prime fraud debunker, Virgil (Romany Malco) on an investigation of a dubious automotive "accident" near Vegas, John sees an opportunity to get a promotion, though he is concerned about returning to the playing game. Before leaving he turns into concerned with his eccentric co-employee Jill (Sarah Silverman), a dalliance that has the potential to turn out to be an actual relationship.
Quickly John is on the street with Virgil, where they encounter a collection of offbeat characters, together with a wheelchair-bound stripper (Emmanuelle Chriqui), a nude militant (Tim Blake Nelson), a park Ranger (Jesse Garcia), and a carnival human torch (John Cho). Whereas Virgil is the supposed leader of the investigation, it's John who begins to finally assert himself, pushing the case closer to a conclusion.
By means of the journey, John's confidence builds, and he realizes that he can't escape his gambling habit by operating away from it-it is going to comply with him wherever he goes. It's only when he returns to Vegas and his experiences there lastly ship him on the trail to breaking free.
First time author/director Hue Rhodes' "Saint John of Las Vegas" follows the wild and funny journey a man has to take to find there's a couple of option to hit the jackpot in life.
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